Peer-reviewed Research Articles
- E Franco, M Gagrani, HL Scanga, RG Areauz, CT Chu*, KK Nischal. 2023. Variable phenotype of congenital corneal opacities in bilallelic CYP1B1 pathogenic variants. Cornea, in press.
- M Verma, L Francis, BN Lizama, J Callio, G Fricklas, KZQ Wang, BA Kaufman, L D'Aiuto, DB Stolz, SC Watkins, VL Nimgaonkar, A Soto-Gutierrez, A Goldstein & CT Chu. iPSC-derived neurons from patients with POLG mutations exhibit decreased mitochondrial content and dendrite simplification. Am J Pathol 193: 201-212.
- PA Otero, G Fricklas, A Nigam, BN Lizama, ZP Wills, JW Johnson & CT Chu. Endogenous PTEN-induced kinase 1 regulates dendritic architecture and spinogenesis. J Neurosci, 42: 7848-7860. 10.1523/JNEUROSCI.0785-22.2022
- CT Chu. (2022) Mitochondria in neurodegeneration. Curr Opin Physiol. 26: 100532. 10.1016/j.cophys.2022.100532
- E Franco, N Iqbal, PR Shah, M Alabek, KS Tripi, C Prescott, HL Scanga, CT Chu* & KK Nischal*. Congenital corneal opacity in 22q11.2 deletion syndrome: a case series. Cornea In press. *Co-senior authors.
- M Verma, BN Lizama & CT Chu. (2021) Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration. Transl Neurodegener 11:3. https://rdcu.be/cFHMm
- O Lopes Abath Neto, ZA Koretz, AI Wald, PP Rath, M Nikiforova & CT Chu. Molecular profiling of renal cell carcinoma presenting as iris metastasis. Am J Ophthal Case Reports 27: 101599.
- PR Shah, B Chauhan, CT Chu, J Kofler, KK Nischal. 2022. Ocular phenotype of Peters-Plus syndrome. Cornea 41:219–223.
- WY Sun, VA Tyurin, K Mikulska-Ruminska, IH Shrivastava, TS Anthonymuthu, YJ Zhai, MH Pan, HB Gong, DH Lu, J Sun, WJ Duan, S Korolev, AY Abramov, PR Angelova, I Miller, O Beharier, GW Mao, HH Dar, AA Kapralov, AA Amoscato, TG Hastings, JT Greenamyre, CT Chu, Y Sadovsky, I Bahar, H Bayır, YY Tyurina, RR He, VE Kagan. 2021. Phospholipase iPLA2b averts ferroptosis by eliminating a redox lipid death signal. Nature Chem Biol 17: 465-476.
- Y Liu, TB Lear, M Verma, KZQ Wang, PA Otero, AC McKelvey, SR Dunn, E Steer, NW Bateman, C Wu, Y Jiang, NM Weathington, M Rojas, CT Chu*, BB Chen*, RK Mallampalli*. 2020. Chemical Inhibition of Fbxo7 Reduces Inflammation and Confers Neuroprotection by Stabilizing the Mitochondrial Kinase PINK1. JCI Insight 5: e131834. doi: 10.1172/jci.insight.131834 *co-senior authors.
- M Verma, J Zhu, KZQ Wang & CT Chu. 2020. Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1 (PINK1) via upregulation of Bcl-2-associated athanogene 6 (BAG6). J Biol Chem, 295: 7865-7876. https://www.sciencedirect.com/science/article/pii/S0021925817494294
- R Ojha, NM Leli, A Onorati, S Pia, II Verginadi, F Tameir, VW Rebecca, CI Chude, S Murugan, C Fennelly, E Noguera-Ortega, CT Chu, S Liu, X Xu, Clemens Krepler, M Xiao, Wei Xu, DT Frederick, G Boland, TC Mitchell, GC Karakousis, LM Schuchter, KT Flaherty, G Zhang, M Herlyn, C Koumenis, RK Amaravadi. (2019) ER translocation of the MAPK pathway drives therapy resistance in BRAF-mutant melanoma. Cancer Discov, 9: 396-415.
- KZQ Wang*, E Steer*, PA Otero*, NW Bateman, MH Cheng, AL Scott, C Wu, I Bahar, YT Shih, YP Hsueh & CT Chu. (2018) PINK1 interacts with VCP/p97 and activates PKA to promote NSFL1C/p47 phosphorylation and dendritic arborization in neurons. eNeuro, 5: ENEURO.0466-18.2018, 1-16.*co-first authors.
F1000 Recommended: Zu-Hang Sheng & Xiu-Tang Cheng: Faculty of 1000 Neuroscience and Neurological Disorders, 7 Jul 2017. https://f1000.com/prime/734664398#eval793559765 - L D’Aiuto, JN Naciri, N Radio, S Tekur, D Clayton, GL Apodaca, R DiMaio, Y Zhu, P Dimitrion, P Piazza, M Demers, J Wook, CT Chu, J Callio, L McClain, R Yolken, J McNulty, P Kinchington, DC Bloom, VL Nimbaonkar. (2018) Generation of three-dimensional human neuronal cultures: Application to modeling CNS viral infections. Stem Cell Res Ther 9: 134
- M Yang, Y Wang, G Liang, Z Xu, CT Chu, H Wei. (2018) Alzheimer’s presenilin-1 mutation render neurons vulnerable to propofol neurotoxicity by calcium dysregulation and impaired autophagy. J Alzheimers Dis 67: 137-147.
- M Verma, J Callio, PA Otero, I Sekler, ZP Wills & CT Chu. (2017) Mitochondrial calcium dysregulation contributes to dendrite degeneration mediated by PD/LBD-associated LRRK2 mutants. J. Neurosci 37: 11151-11165. http://www.jneurosci.org/content/37/46/11151.long
- T Das Banerjee, RY Dagda, M Dagda, CT Chu, E Vasquez-Mayorga, M Rice, RK Dagda. PINK1 and mitochondrial PKA regulate mitochondrial trafficking in dendrites of cortical neurons. (2017) J Neurochem 142: 545-559.
- AM Gusdon, J Callio, G DiStefano, RM O’Doherty, B Goodpaster, PM Coen & CT Chu. (2017) Exercise Increases Mitochondrial Complex I Activity and DRP1 Expression in the Brains of Aged Mice. Exp Gerontol 90: 1-13.
- S Ravi, KA Pena, CT Chu, K Kiselyov. (2016) Biphasic regulation of lysosomal exocytosis by oxidative stress. Cell Calcium, 60: 356-362.
- R Di Maio, PJ Barrett, EK Hoffman, CW Barrett, A Zharikov, A Borah, X Hu, J McCoy, CT Chu, EA Burton, TG Hastings, JT Greenamyre. (2016) a-Synuclein binds TOM20 and inhibits mitochondrial protein import in Parkinson’s disease. Sci Transl Med 8: 342ra78.
- NQ Richards, JK Kofler, CT Chu, ST Stefko (2016) Intraocular synovial sarcoma. Retin Cases Brief Rep In press.
- K Banerjee, S Munshi, H Xu, DE Frank, HL Chen, CT Chu, J Yang, S Cho, VE Kagan, TT Denton, YY Tyurina, JF Jiang, GE Gibson. (2016) Mild mitochondrial metabolic deficits by a-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer’s disease. Neurochem Int 96:32-45.
- VE Kagan, J Jiang, Z Huang, YY Tyrurina, C Desbourdes, C Cottet-Rousselle, H Dar, M Verma, VA Tyurin, AA Kapralov, A Cheikhi, G Mao, D Stolz, CM S. Croix, S Watkins, Z Shen, Y , ML Greenberg, M Tokarska-Schlattner, M Boissan, M-L Lacombe, RM Epand, CT Chu, R Mallampalli, H Bayır, U Schlattner. (2016) NDPK-D (NM23-H4)-dependent externalization of cardiolipin during elimination of depolarized mitochondria. Cell Death Differ 23: 1140-1151.
- M Kostic, MHR Ludtmann, H Bading, M Hershfinkel, E Steer, CT Chu, AY Abramov & I Sekler. (2015) PKA phosphorylation of NCLX reverses mitochondrial calcium overload and depolarization, promoting survival of PINK1-deficient dopaminergic neurons. Cell Reports 13: 376-386. http://www.sciencedirect.com/science/article/pii/S2211124715009924
- AK Au, Y Chen, L Du, CM Smith, MD Manole, SA Baltagi, CT Chu, RK Aneja, H Bayır, PM Kochanek & RSB Clark. (2015) Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing brain and in primary cortical neurons in vitro. Biochim. Biophys. Acta (Molecular Basis of Disease) 1852: 1902-1911. doi:10.1016/j.bbadis.2015.06.007
- AM Gusdon, F Fang, J Chen, CE Mathews, W Li, CT Chu, JQ Ding & SD Chen (2015) Association of the mt-ND2 5178A/C polymorphism with Parkinson’s disease. Neurosci Lett 587: 98-101. PMID: 25511548
- M Bueno, M Mosher, C Kamga, C Corey, D Stolz, C StCroix, M Rojas, S Shiva, CT Chu & AL Mora. (2015) PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest 125: 521-538. PMCID: PMC4319413
- NK Mesiwala, CT Chu, LV Raju. (2014) Infectious crystalline keratopathy predominantly affecting the posterior cornea. Int J Clin Pathol 7: 5250-5253. PMCID: PMC4152095
- A Nuschke, M Rodrigues, DB Stolz, CT Chu, L Griffith & A Wells. (2014) Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation. Stem Cell Res Ther 5: 140 (14 pages) PMID: 25523618
- LH Sanders, J McCoy, X Hu, PG Mastroberardino, BC Dickinson, CJ Chang, CT Chu, B Van Houten, JT Greenamyre. (2014) Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson’s disease. Neurobiol Dis 70: 214-223. PMCID: PMC4144978
- Ed Plowey, JW Johnson, D Eisenberg, NM Valentino, YJ Liu & CT Chu. Mutant LRRK2 overexpression in cultured cortical neurons elicits glutamatergic synapse activity and excitotoxic neurite degeneration. Biochim. Biophys. Acta (Molecular Basis of Disease), in press. http://www.sciencedirect.com/science/article/pii/S0925443914001446
- VP Patel & CT Chu. (2014) Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: Implications for Parkinson’s disease. Exp. Neurol., in press. http://dx.doi.org/10.1016/j.expneurol.2014.04.024.
- KZQ Wang, J Zhu, RK Dagda, G Uechi, SJ Cherra III, AM Gusdon, M Balasubramani & CT Chu. (2014) ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription. Mitochondrion, in press. http://dx.doi.org/10.1016/j.mito.2014.04.008.
- BB Chen, TA Coon, JR Glasser, C Zou, B Ellis, T Das, AC McKelvey, S Rajbhandari, T Lear, C Kamga, S Shiva, CJ Li, JM Pilewski, J Callio, CT Chu, A Ray, P Ray, YY Tyurina, VE Kagan, and RK Mallampalli. (2014) E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Cell Reports 7: 476-487. http://dx.doi.org/10.1016/j.celrep.2014.02.048.
- RK Dagda, I Pien, R Wang, J Zhu, KZQ Wang, J Callio, TD Banerjee, RY Dagda & CT Chu. Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through Protein Kinase A. J Neurochem 128: 864-877.
- CK Pride, L Mo, K Quesnelle, RK Dagda, D Murillo, L Geary, C Corey, R Portella, S Zharikov, C St Croix, S Maniar, CT Chu, N Khoo & S Shiva (2014) Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischemia reperfusion. Cardiovascular Res, 101: 57-68.
- CT Chu*, J Ji, RK Dagda, JF Jiang, YY Tyurina, AA Kapralov, VA Tyurin, N Yanamala, IH Shrivastava, D Mohammadyani, KZQ Wang, J Zhu, J Klein-Seetharaman, K Balasubramanian, AA Amoscato, G Borisenko, Z Huang, AM Gusdon, A Cheikhi, EK Steer, R Wang, C Baty, S Watkins, I Bahar, H Bayır* & VE Kagan* (2013) Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nature Cell Biol 15:1197-1205. DOI: 10.1038/ncb2837. *Co-senior authors. Featured in Science magazine’s Editors’ Choice, 25 Oct 2013 (Science 342: 403, 2013) F1000 Recommended: Tavernarakis & Nikoletopoulou: F1000 Cell Biology, 28 Oct 2013; Sheng & Puri: F1000 Neuroscience, 06 Dec 2013; Yoshimori & Hasegawa: F1000 Cell Biology, 12 Dec 2013; Osiewacz: F1000 Microbiology, 19 Dec 2013; Klionsky: F1000 Cell Biology, 20 Jan 2014.
- SJ Cherra III, E Steer, AM Gusdon, K Kiselyov & CT Chu. (2013) Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am J Pathol, 182: 474-484. PMCID: PMC3562730
- JE Knickelbein, J Kovarik, DK Dhaliwal & CT Chu. (2013) Acanthamoeba keratitis: A clinico-pathologic case report and review of the literature. Human Pathol, 44: 918-922.
- VP Patel, DB DeFranco & CT Chu. (2012) Altered transcription factor trafficking in oxidatively-stressed neuronal cells. Biochim. Biophys. Acta 1822: 1773-1782. PMCID:PMC3628596
- J Zhu, A Gusdon, H Cimen, B Van Houten, E Koc & CT Chu. (2012) Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity. Cell Death Dis 3: e312. doi: 10.1038/cddis.2012.46. PMCID: PMC3366080
- AM Gusdon, J Zhu, B Van Houten & CT Chu. (2012) ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiol Dis 45: 962-972. PMCID:PMC3291101
- RK Dagda, A Gusdon, I Pien, S Strack, S Green, B Van Houten, SJ Cherra III & CT Chu. (2011) Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson’s disease. Cell Death Differ 18: 1914-1923. PMCID: PMC3177020
- VS Van Laar, BA Arnold, SJ Cassady, CT Chu, EA Burton & SB Berman. (2011) Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Hum Mol Genet 20: 927-940. PMCID: PMC3033183. F1000 Recommended: Marie Hardwick: Faculty of 1000 Biology, 23 Feb 2011.
- X Hu, Z Weng, CT Chu, L Zhang, G Cao, Y Gao, A Signore, J Zhu, T Hastings, JT Greenamyre & J Chen. (2011) Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the ASK1 signaling cascade. J. Neurosci. 31: 247-261. PMCID: PMC3078571.
- SJ Cherra III, SM Kulich, G Uechi, M Balasubramani, J Mountzouris, BW Day & CT Chu. (2010) Regulation of the autophagy protein LC3 by phosphorylation. J. Cell. Biol. 190: 533-539. doi: 10.1083/jcb.201002108. PMC2928022. F1000 Recommended: Eui-Ju Choi: Faculty of 1000 Biology, 21 Sep 2010
- DM Bear, A Williams, CT Chu, CH Coyle, CR Chu. (2010) Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content, J Orthop Res 28: 546-552. F1000 Recommended: Jurvelin & Saarakkala: Faculty of 1000 Medicine, 08 Feb 2010
- CR Chu, CH Coyle, CT Chu, M Szczodry & V Seshadri (2010) In Vivo Effects of Single Intra-articular Injection of 0.5% Bupivacaine on Articular Cartilage, J. Bone Joint Surg Am. 92: 599-608.
- H Bayir, A Kapralov, J Jiang, Z Huang, YY Tyurina, VA Tyurin, Q Zhao, NA Belikova, II Vlasova, A Maeda, J Zhu, HM Na, PG Mastroberardino, LJ Sparvero, AA Amoscato, CT Chu, JT Greenamyre & VE Kagan (2009) Peroxidase mechanism of lipid dependent cross-linking of synuclein with cytochrome c: Protection against apoptosis versus delayed oxidative stress in Parkinson disease. J Biol Chem 284: 15951-15969. PMID: 19351880; PMCID: PMC2708890
- LM Voeghtly, IB Thørgersen, Z Valnickova, KW Sanggaard, CT Chu, TD Oury & JJ Enghild (2009) Potential clinical importance of the activation peptide of prostate-specific antigen. Int J Clin Exp Pathol 2: 588-598. PMID: 19636406, PMCID: PMC2713450
- RK Dagda, SJ Cherra III, SM Kulich, A Tandon, D Park & CT Chu. (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 284: 13843-13855. PMID: 19279012; PMCID: PMC2679485. F1000 Recommended: Mark A Smith: Faculty of 1000 Medicine, 13 Apr 2010
- PG Mastroberardino, EK Hoffman, MP Horowitz, R Betarbet, G Taylor, D Cheng, HM Na, CA Gutekunst, M Gearing, JQ Trojanowski, M Anderson, CT Chu, J Peng, JT Greenamyre. (2009) A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiol Dis 34:417-431. PMID: 19250966; PMCID: PMC2784936
- L Du, RW Hickey, H Bayir, SC Watkins, VA Tyurin, F Guo, PM Kochanek, LW Jenkins, J Ren, G Gibson, CT Chu, VE Kagan & RSB Clark. (2009) Starving neurons show sex difference in autophagy. J Biol Chem, 284: 2383-2396. PMID: 19036730; PMC2629091
- RK Dagda, J Zhu, SM Kulich & CT Chu. (2008) Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress. Autophagy, 4: 770-782. PMCID: PMC2574804; PMID: 18594198.
- C Horbinski, S Dacic, RE McClendon, K Cieply, M Datta, DJ Brat & CT Chu (2008) Chordoid glioma: A case report and molecular characterization of 5 cases. Brain Pathol 19: 439–448. PMID: 18652591
- ED Plowey, SJ Cherra III, Y-J Liu & CT Chu (2008) Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem 105: 1048-1056. PMID: 18182054; PMCID: PMC2361385
- Y Lai, RW Hickey, Y Chen, H Bayir, M Sullivan, CT Chu, PM Kochanek, CE Dixon, LW Jenkins, SH Graham, SC Watkins, RSB Clark. (2008) Autophagy is increased after traumatic brain injury in mice is partially inhibited by the antioxidant g-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab, 28: 540-550. PMID: 17786151
- K Onuma, CT Chu & DJ Dabbs. (2007) Asymptomatic giant cell (temporal) arteritis involving bilateral adnexa: Case report and literature review. Int J Gynecol Pathol. 26: 352-355. PMID: 17581424
- SM Kulich, C Horbinski, M Patel & CT Chu. (2007) 6-Hydroxydopamine induces mitochondrial ERK activation. Free Rad Biol Med. 43: 372-383. PMID 17602953; PMCID: PMC2023873
- CP Ramsey, CA Glass, MB Montgomery, KA Lindl, GP Ritson, LA Chia, RL Hamilton, CT Chu & KL Jordan-Sciutto. (2007) Expression of Nrf2 in Neurodegenerative Diseases. J Neuropathol Exp Neurol, 66: 75-85. PMID: 17204939; PMC2253896
- D Hu, P Cao, E Thiels, CT Chu, G Wu, TD Oury & E Klann. (2007) Hippocampal long-term potentiation, memory and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiol Learning Mem, 87: 372-384. PMC1847321; PMID: 17129739
- ME Couce, R Medina-Flores, M Wong & CT Chu. (2007) Occult germ cell tumor presenting as spontaneous intracerebral hemorrhage. Histopathol, 50: 789-793. PMID: 17493243
- JH Zhu, C Horbinski, F Guo, S Watkins, Y Uchiyama & CT Chu (2007). Regulation of autophagy by extracellular signal regulated protein kinases during 1-methyl-4-phenylpyridinium injury. Am J. Pathol, 170: 75-86. PMID: 17200184; PMCID: PMC1762689
- JJ Jennings, J Zhu, Y Rbaibi, X Luo, CT Chu & K Kiselyov (2006). Mitochondrial aberrations in mucolipidoses type IV. J Biol Chem 281: 39041-39050. PMID: 17056595
- EM Chalovich, JH Zhu, J Caltagarone, R Bowser & CT Chu (2006) Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cells. J. Biol. Chem, 281: 17870-17881. PMC1876691; PMID: 16621793
- F Koc, S Kargi, AW Biglan, CT Chu & JS Davis (2006) The aetiology in pediatric aphakic glaucoma. Eye, 20: 1360-1365 PMID: 16284603
- CT Chu, JH Zhu, G Cao, A Signore, S Wang & J Chen (2005) Apoptosis-inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells. J. Neurochem, 94: 1685-1695. PMC1868549; PMID: 16156740
- J Callio, TD Oury & CT Chu (2005) Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains J Biol Chem, 280:18536-18542. PMC1885201; PMID: 15755737
- ML McClure, DA Linseman, CT Chu, PA Barker, RJ Bouchard, SS Le, TA Laessig and KA Heidenreich. (2004) The p75 neurotrophin receptor mediates autophagy and death of cerebellar Purkinje neurons. J. Neurosci, 24(19): 4498-4509. PMC1876689; PMID: 15140920
- CR Chu, D Lin, J Geisler, CT Chu, FH Fu & Y Pan. (2004) Arthroscopic microscopy of articular cartilage using optical coherence tomography. Am J Sports Med. 32: 699-709. PMID: 15090388
- C Hope, J Mettenburg, SL Gonias, ST DeKosky, MI Kamboh and CT Chu. (2003) Functional analysis of plasma a2-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion. Neurobiol Dis 14(3): 504-512. PMID: 14678766
- ME Beckner, JYK Lee, SS Schochet Jr, & CT Chu. (2003) Intracranial extramedullary hematopoiesis associated with pilocytic astrocytoma. Acta Neuropathol, 106: 584-587. PMID: 14520481
- JH Zhu, F Guo, J Shelburne, S Watkins & CT Chu. (2003) Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathol, 13: 473-481. PMC1911206; PMID: 14655753
- CT Chu & JH Zhu (2003) Subcellular compartmentalization of P-ERK in the Lewy body disease substantia nigra. Ann NY Acad Sci 991: 288-290.
- SM Kulich & CT Chu. (2003) Role of reactive oxygen species in extracellular signal-regulated protein kinase phosphorylation and 6-hydroxydopamine cytotoxicity J Biosci 28: 83-89. PMC1868550; PMID: 12682429
- JH Zhu, SM Kulich, TD Oury & CT Chu. (2002) Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases. Am J Pathol 161: 2087-2098. PMC1850911; PMID: 12466125
- M Estevez, C Chu & M Pless. (2002) Small B-cell lymphoma presenting as diffuse dural thickening with cranial neuropathies. J Neuro-onc, 59: 243-247. PMID: 12241122
- CL Fattman, CT Chu, SM Kulich, TD Oury. (2001) Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment. Free Rad Biol Med. 31: 1198-1207. PMID: 11705698
- AM Scarrow, EI Levy, PC Gerszten , SM Kulich, CT Chu, and WC Welch (2001). Epidermoid cyst of the thoracic spine. Clin. Neurol. Neurosurg. 103: 220-222. PMID: 11714565
- SM Kulich & CT Chu. (2001) Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: Implications for Parkinson's disease. J Neurochem 77: 1058-1066. PMC1868550; PMID: 11359871
- E Thiels, NN Urban, GR Gonzalez-Burgos, BI Kanterewicz, G Barrionuevo, CT Chu, TD Oury & E Klann. (2000) Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase. J Neurosci 20: 7631-7639. PMID: 11027223
- TJ Cummings, CT Chu, SC Pollock, GK Klintworth. (2000) Optic nerve astrocytoma associated with angiogenesis and neovascular glaucoma. Ophthalmic Practice 18 :227-230.
- CT Chu, J Caruso, T Cummings, J Ervin, C Rosenberg & CM Hulette. (2000) Ubiquitin immunochemistry as a diagnostic aid for community pathologists evaluating patients who have dementia Modern Pathol 13: 420-426. PMID: 10786809. Selected for abstraction in the 2001 Yearbook of Pathology and Clinical Pathology, Mosby-Year Book, Inc, St Louis, MO.
- TJ Cummings, CM Hulette, DC Longee, KS Bottom, RE McLendon & CT Chu. (1999) Gliomatosis cerebri: Cytologic and autopsy findings in a case involving the entire neuraxis. Clin Neuropathol 18: 190-197. PMID: 10442461
- CT Chu, DN Howell, JC Morgenlander, CM Hulette, RE McLendon & SE Miller. (1999) Electron microscopic diagnosis of human flavivirus encephalitis: Use of confocal microscopy as an aid. Am J Surg Pathol, 23: 1217-1226. PMID: 10524522
- GB Mackensen, B Nellgård, Y Miura, CT Chu, F Dexter, RD Pearlstein & DS Warner. (1999) Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat Anesthesiology 90: 873-881. PMID: 10078690
- CT Chu, LG Leithe, LB Goldstein & CM Hulette (1998) Diagnosis of intracranial vasculitis: A multidisciplinary approach J Neuropath Exp Neurol 57: 30-38. PMID: 9600195
- CT Chu, KD Everiss, CJ Wikstrand, SK Batra, H-J Kung & DD Bigner (1997) Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII) Biochem J. 324: 855-861. PMID: 9210410
- Z Valnickova, IB Thøgersen, S Christensen, CT Chu, SV Pizzo & JJ Enghild (1996) Activated human plasma carboxypeptidase B is retained in the blood by binding to a2–macroglobulin and pregnancy zone protein J Biol Chem 271: 12937-12943. PMID: 8662763
- WD Bradford, D Anthony, CT Chu & SV Pizzo (1996) Career characteristics of graduates of a medical scientist training program, 1970-1990 Acad Med 71: 484-487. PMID: 9114867
- DJ Webb, IM Hussaini, AM Weaver, TL Atkins, CT Chu, SV Pizzo, GK Owens & SL Gonias (1995) Activated a2–macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism independent of growth-factor-carrier activity Eur J Biochem 234: 714-722. PMID: 8575427
- XD Ren, AW Dodds, JJ Enghild, CT Chu & SKA Law (1995) The effect of residue 1106 in the thiolester mediated covalent binding reaction of human complement protein C4 and the monomeric rat a macroglobulin a1I3 FEBS Lett 368: 87-91. PMID: 7542207
- UK Misra, CT Chu, G Gawdi & SV Pizzo (1994) The relationship between LRP/a2M receptors and the newly described a2M signaling receptor J Biol Chem 269: 18303-18306. PMID: 7518427
- UK Misra, CT Chu, G Gawdi & SV Pizzo (1994) Evidence for a second a2-macroglobulin receptor J Biol Chem 269: 12541-12547. PMID: 7513689
- CT Chu, GC Howard, UK Misra & SV Pizzo (1994) a2–Macroglobulin: A sensor for proteolysis Ann NY Acad of Sci 737: 291-307. PMID: 7524403
- CT Chu, TD Oury, JJ Enghild & SV Pizzo (1994) Adjuvant-free in vivo targeting: Antigen delivery by a2-macroglobulin enhances antibody formation J Immunol 152: 1538-1545. PMID: 7509826. Selected for abstraction in the 1995 Year Book of Allergy , Asthma & Clinical Immunology, Mosby-Year Book, Inc, St Louis, MO, p. 47-49.
- UK Misra, CT Chu, DS Rubenstein, G Gawdi & SV Pizzo (1993) Receptor-recognized a2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages Biochem J 290: 885-891. PMID: 7681282
- CT Chu and SV Pizzo (1993) Receptor-mediated antigen delivery into macrophages: Complexing antigen to a2-macroglobulin enhances presentation to T–cells J Immunol 150: 48–58. PMID: 7678035
- CT Chu, DS Rubenstein, JJ Enghild & SV Pizzo (1991) Mechanism of insulin incorporation into a2-macroglobulin: Implications for the study of peptide and growth factor binding Biochemistry 30: 1551–1560. PMID: 1704257
- CT Chu (1989) Functional design and prey capture dynamics in an ecologically generalized surfperch (Embiotocidae) J Zool, Lond 217: 417–440.
Reviews, Commentaries & Book Chapters
- MA Artyukhova, YY Tyurina, CT Chu, TM Zharikova, H Bayir, VE Kagan, PS Timashev. (2019) Interrogating Parkinson’s disease associated redox targets: Potential application of CRISPR editing. Free Radic Biol Med 144: 279-292.
- CT Chu. (2019) Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases. Neurobiol Dis 122: 23-34. DOI: 10.1016/j.nbd.2018.07.015
- M Verma, Z Wills & CT Chu. (2018) Excitatory dendritic mitochondrial calcium toxicity: Implications for Parkinson’s and other neurodegenerative diseases. Front Neurosci 12: 523 (12 pages). DOI:10.3389/fnins.2018.00523
- CT Chu. (2018) Multiple pathways for mitophagy: A neurodegenerative conundrum for Parkinson’s disease. Neurosci Lett 697: 66-71. P
- I Kang, CT Chu, BA Kaufman. (2018) The mitochondrial transcription factor TFAM in neurodegeneration: Emerging evidence and mechanisms. FEBS Lett 592(5):793-811. DOI:10.1002/1873-3468.12989
- CT Chu. Autophagy. Reference Module in Neuroscience and Biobehavioral Psychology 2017, 1–4, Elsevier. http://dx.doi.org/10.1016/B978-0-12-809324-5.03651-8.
- L Galluzzi…CT Chu…, and Guido Kroemer. Molecular definitions of autophagy and related processes. EMBO J 36: 1811-1836.
- DJ Klionsky… CT Chu … et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (2nd edition). Autophagy 12: 1-222.
- EK Steer, MK Dail & CT Chu. (2016) PINK1 as a sensor for mitochondrial function: Dual roles. In The Functions, Disease-Related Dysfunctions and Therapeutic Targeting of Neuronal Mitochondria. (VK Gribkoff, EA Jonas, JM Hardwick, Editors). John Wiley and Sons, Inc., New Jersey, pp. 240-253.
- EK Steer, MK Dail & CT Chu. (2015) Beyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health. Antioxidants Redox Signaling 22: 1047-1059.
- CT Chu, H Bayir & VE Kagan. (2014) LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: Implications for Parkinson disease. Autophagy 10: 376-378. doi: 10.4161/auto.27191. PMID: 24351649
- VE Kagan, CT Chu, YY Tyurina, A Cheikhi & H Bayir. (2014) Cardiolipin asymmetry, oxidation and signaling. Chemistry and Physics of Lipids 179: 64-69. PMCID: PMC3973441
- M Verma, EK Steer & CT Chu. (2013) ERKed by LRRK2: A cell biological perspective on hereditary and sporadic Parkinson’s disease. Biochim Biophys Acta (Molecular Basis of Disease) In press. PMCID: PMC4016799
- CT Chu. 583. Autophagy. In Encyclopedia of Neurological Sciences 2E, 2nd edition. (Michael J. Aminoff and Robert B. Daroff, Editors). Elsevier, In press for Jan 2014.
- J Zhu, KZQ Wang & CT Chu. (2013) After the banquet: Mitochondrial biogenesis, mitophagy and cell survival. Autophagy In press.
- E Oczypok, TD Oury & CT Chu. (2013) It’s a cell eat cell world: Autophagy and phagocytosis. Am J Pathol 182: 612-622. PMCID:PMC3589073
- ZH Sheng & CT Chu. (2012) Chapter 16. Neuronal mitochondrial transport and turnover via mitophagy. In: Autophagy of the Nervous System: Cellular Self-Digestion in Neurons and Neurological Diseases (Editors: Yue and Chu). World Scientific Press, Singapore, pp. 375-405.
- SJ Cherra III & CT Chu. (2012) Chapter 5. Maintaining autophagic balance: a role for brakes. In: Autophagy of the Nervous System: Cellular Self-Digestion in Neurons and Neurological Diseases (Editors: Yue and Chu). World Scientific Press, Singapore, pp. 105-125.
- DK Simon, CT Chu & RH Swerdlow (2012) Mitochondria and Parkinson’s Disease. Parkinsons Dis 2011: Article ID 261791, 2 pages doi:10.4061/2011/261791. PMCID:PMC3437634
- DJ Klionsky, FC Abdalla, H Abeliovich, RT Abraham… CT Chu … et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544. PMCID: PMC3404883
- CT Chu. (2012) Introduction. Autophagy Dysregulation in Neuropathology. Brain Pathol 22: 80-81.
- DJ Klionsky, EH Baehrecke, JH Brumell, CT Chu, P Codogno, AM Cuervo, J Debnath, V Deretic, Z Elazar, EL Eskelinen, S Finkbeiner, J Fueyo-Margareto, D Gewirtz, M Jäättelä, G Kroemer, B Levine, TA Melia, N Mizushima, DC Rubinsztein, A Simonsen, A Thorburn, M Thumm, SA Tooze. (2011) A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy 7: 1273-1294. PMCID: PMC3359482
- J Zhu, RK Dagda & CT Chu (2011) Ch. 21. Monitoring mitophagy in neuronal cell cultures. In Neurodegeneration: Methods and Protocols. (G Manfredi & JK Fujita, Editors) Humana Press, New York, NY. Methods in Molecular Biology, 793: 325-339.
- CT Chu & SB Berman (2011) Ch. 7. Mitochondrial fission-fusion and Parkinson’s disease: A dynamic question of compensatory networks. In Mitochondrial Dynamics and Neurodegeneration. (B Lu, Editor) Springer Publishing Co, New York, NY. pp. 197-213.
- CT Chu (2011) Autophagy in different flavors: Dysregulated protein degradation in neurological diseases. Neurobiol Dis 43: 1-3.
- VP Patel & CT Chu (2011) Nuclear transport, oxidative stress, and neurodegeneration. Int J Clin Exp Pathol, 4: 215-229. PMCID: PMC3071655
- CT Chu (2011) Diversity in the regulation of autophagy & mitophagy: Lessons from Parkinson’s disease. Parkinsons Dis, Vol 2011: Article ID 789431, 8 pages. doi:10.4061/2011/789431 (peer reviewed) PMCID: PMC3096099
- AR Gusdon & CT Chu (2011) To eat or not to eat: Neuronal metabolism, mitophagy and Parkinson’s disease. Antioxidant Redox Signaling 14: 1979-1987 (peer reviewed)
- ED Plowey & CT Chu (2010) Synaptic dysfunction in genetic models of Parkinson's disease: A Role for Autophagy? Neurobiol Dis 43: 60-67 (peer reviewed) PMC3049988
- J Zhu & CT Chu (2010) Mitochondrial dysfunction in Parkinson’s disease. J Alzheimer Dis 20: S325-S334. (peer reviewed)
- CT Chu (2010) A pivotal role for PINK1 and autophagy in mitochondrial quality control: Implications for Parkinson disease. Human Mol Genetics 19: R28-R37. (peer reviewed) PMCID: PMC2875056
- SJ Cherra III, RK Dagda & CT Chu (2010) Autophagy and Neurodegeneration: Survival at a cost? Neuropathology and Applied Neurobiology 36: 125-132. NIHMS 184089.
- RK Dagda & CT Chu (2009) Mitochondrial quality control: Insights on how Parkinson’s disease related genes PINK1, Parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis. J Bioenerg Biomembr, 41: 473-479. PMID: 20012177; PMCID: PMC2809778.
- CT Chu. (2010) Tickled PINK1: Mitochondrial homeostasis and autophagy in recessive parkinsonism. BBA-Molecular Basis of Disease 1802: 20-28 (peer reviewed). PMID: 19595762; PMCID: PMC2790548.
- SJ Cherra III, RK Dagda, A Tandon & CT Chu. (2009) Mitochondrial autophagy as a compensatory response to PINK1 deficiency. Autophagy, 5: 1213-1214. PMID: 19786829; PMCID: PMC2841445 [Available on 2010/5/11]
- RK Dagda, J Zhu & CT Chu. (2009) Mitochondrial kinases in Parkinson's disease: Converging insights from neurotoxin and genetic models. Mitochondrion, 9: 289-298 (peer reviewed ). PMID: 19563915; PMCID: PMC2748152
- CT Chu, Ed Plowey, RK Dagda, RW Hickey, SJ Cherra III & RSB Clark. (2009) Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models. Meth Enzymol, 453: 217-249. PMID: 19216909; PMCID: PMC2669321
- SJ Cherra III & CT Chu. (2008) Autophagy in neuroprotection and neurodegeneration: a question of balance. Future Neurol, 3: 309-323. PMID: 18806889; PMCID: PMC2544613 (peer reviewed)
- DJ Klionsky, H Abeliovich, P Agostinis ... CT Chu et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 4: 151-175. PMID: 18188003; PMC2654259
- CT Chu (2008) Eaten alive: autophagy and neuronal cell death after hypoxia-ischemia. Am J Pathol, 172: 284-287. PMID: 18202199; PMCID: PMC2312352
- RS Clark, H Bayir, CT Chu, SM Alber, PM Kochanek & SC Watkins (2008) Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy, 4: 88-90. PMID: 17957135
- CT Chu, J Zhu & R Dagda (2007) Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: Implications for neurodegeneration and cell death. Autophagy, 3: 663-666. PMID: 17622797; PMCID: PMC2779565
- CT Chu, E Plowey, Y Wang, V Patel & KL Jordan-Scuitto (2007) Location, location, location: Altered transcription factor trafficking in neurodegeneration. J Neuropath Exp Neurol, 66: 873-883. PMID: 17917581; PMC2220049
- K Kiselyov, JJ Jennings, Y Rbaibi & CT Chu (2007) Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy 3: 259-262. PMID: 17329960; PMCID: PMC2777544
- CT Chu & DC Hooper (2006) Reactive oxygen/nitrogen species at the fulcrum of life-death decisions. A commentary on "Peroxynitrite transforms Nerve Growth Factor into an apoptotic factor for motor neurons." Free Radic Biol Med 41: 1629-1631. PMID: 17145550
- VE Kagan, YY Tyurina, H Bayir, CT Chu, AA Kapralov, II Vlasova, NA Belikova, VA Tyurin, A Amoscato, M Epperly, J Greenberger, S DeKosky, AA Shvedova, & J Jiang. (2006) The "pro-apoptotic genies" get out of mitochondria: Oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes . Chem Biol Interact 163: 15-28. PMID: 16797512
- CT Chu. (2006) Autophagic stress in neuronal injury and disease. J Neuropath Exp Neurol, 65: 423-432. PMC1885377, PMID: 16772866
- C Horbinski & CT Chu (2005) Kinase signaling cascades in the mitochondrion: A matter of life or death Free Radic Biol Med. 38: 2-11. PMID: 15589366 (peer reviewed). “Free Radical Biology & Medicine Top most cited paper 2005 - 2007 Award”
- CT Chu, DJ Levinthal, SM Kulich, EM Chalovich, and DB DeFranco (2004) Oxidative neuronal injury: The dark side of ERK 1/2. Eur J Biochem, 271: 2060-2066. doi:10.1111/j.1432-1033.2004.04132.x (Cover article). PMC1899467; PMID: 15153095 (peer reviewed)
- CL Fattman, CT Chu, & TD Oury (2004) Experimental models of asbestos-related diseases, Chapter 10 in Pathology of Asbestos-Associated Diseases 2nd ed. (VL Roggli , TD Oury , T. Sporn, Eds) Springer, NY. pp 256-308.
- CT Chu (2003) Book Review: Advances in Neurology Volume 91: Parkinson's Disease (Edited by Ariel Gordin, Seppo Kaakkola and Heikki Teravainen, Lippincott Williams & Wilkins, Philadelphia) Brain Pathol 13: 229-230.
- LB Goldstein, CT Chu, L Gray & CM Hulette (1999) Comment on Angiographically defined primary angiitis of the central nervous system (letter) Neurology, 52: 1302. PMID: 10214774
- CT Chu & GK Klintworth (1999) Applications of microprobe analysis in ocular pathology (invited book chapter). In Biomedical Applications of Microprobe Analysis, 2nd Ed. (P Ingram, JD Shelburne & VL Roggli, Editors) Academic Press, San Diego, CA.
- CT Chu and SV Pizzo (1994) a2–Macroglobulin, complement & biologic defense: Antigens, growth factors, microbial proteases, and receptor ligation. Lab Invest 71: 792-812. PMID: 7528831 (peer reviewed)
Edited Works
Autophagy of the Nervous System: Cellular Self-Digestion in Neurons and Neurological Diseases (Editors: Yue and Chu). World Scientific Press, Singapore, 2012. 440 pp. ISBN – 978-981-4350-44-0.
Clinical cases for CME
- CH Chiang, CT Chu & CA Wiley. (2015) A 67 year old man with multiple sclerosis and new onset cerebellar lesions. (progressive multifocal leucoencephalopathy with superimposed immune reconstitution inflammatory syndrome). Brain Pathol 25: 507-508. doi: 10.1111/bpa.12269
- W Anani, CT Chu, TD Oury. Case 843 – A 30 year old male with a right corneal abrasion (Acanthamoeba keratitis with molecular testing). Electronically published as the Molecular Diagnostics Case of the Month, University of Pittsburgh, Department of Pathology. http://path.upmc.edu/cases/case843.html
- CT Chu. (2013) Unknown Case 1 (large cell neuroendocrine lung carcinoma presenting as choroidal metastasis). USCAP Specialty Conference in Ophthalmic Pathology, Baltimore, MD, Electronically published March 4, 2013. http://www.uscap.org/newindex.htm?102nd/specialtyh.htm
- C Horbinski, CT Chu, D Finegold & MA Virji. (2005) Case 435 – A 10 month-old girl with hypotonia (Pompe Disease, gycogen storage disease type II, infantile onset). Electronically published as the August 2005 Clinical Pathology Case of the Month, University of Pittsburgh, Department of Pathology. http://path.upmc.edu/cases/case435.html.
- TJ Cummings, CT Chu, SC Pollock, GK Klintworth. (2004) Continuing Education Credit Article on Optic Nerve Astrocytoma Associated with Angiogenesis and Neovascular Glaucoma. Clinical & Refractive Optometry 15: 208-215.
- D Ionescu, J Engl & CT Chu (2004) Case 389 – A baby girl with a bulging eye (Plexiform neurofibroma and choroidal harmartoma with pseudosensory corpuscles). Electronically published as the May 2004 Anatomic Pathology Case of the Month, University of Pittsburgh, Department of Pathology, http://path.upmc.edu/cases/case389.html.
- JA Ozolek & CT Chu (2003) Pseudogout of the craniocervical junction. Arch Pathol Lab Med 127: 895. PMID: 12823054
- X Wang & CT Chu (2002) Case 324 – A 27-year-old female with three week history of progressive headache, nausea and vomiting (Anaplastic ependymoma in extraventricular location). Electronically published as the October 2002 Anatomic Pathology Case of the Month, University of Pittsburgh, Department of Pathology, http://path.upmc.edu/cases/case324.html.
- T Cummings, CT Chu & CM Hulette (1999) Spontaneously ruptured Radtke's cleft cyst. Brain Pathol 9: 425-426. PMID: 10219756.
Other publications.
- CT Chu, SJ Cherra & J Callio (2010) LRRK2 antibodies in cultured cells. MJFF PD Online Research, May 19, 2010. http://www.pdonlineresearch.org/responses/25368/179/lrrk2-antibodies-cultured-cells
- CT Chu (2010) PDD and DLB: insight from pathology and genetics? MJFF PD Online Research, Mar 16, 2010. http://www.pdonlineresearch.org/responses/25567/179/pdd-and-dlb-insight-pathology-and-genetics
- CT Chu (2009) LRRKing about autophagy... MJFF PD Online Research. Oct 1, 2009. http://www.pdonlineresearch.org/responses/783/179/lrrking-about-autophagy
- CT Chu (2009) PINK1, TRAP1, HtrA2/Omi, Parkin: Convergence on mitochondrial quality control? MJFF PD Online Research. Sept 24, 2009. www.pdonlineresearch.org
- CT Chu. (2009) Biological pathways regulated by PINK1. WikiGenes. May 22, 2009. http://www.wikigenes.org/e/gene/e/65018.html
- CT Chu. (2009) Mitochondrial dynamics: Is there parkin' in the PINK1 zone? Michael J Fox Foundation PD Online Research. May 5, 2009. www.pdonlineresearch.org
- RK Dagda, SJ Cherra & CT Chu. (2009). Neurite Morph Macro (3/16/2009) and GFP-LC3 (4/4/09) and Mitochondrial Morphology (4/4/09) Macro. ImageJ Wiki http://imagejdocu.tudor.lu/doku.php?do=search&id=chu+lab
- SV Pizzo, CT Chu, & TD Oury (1994) Immune response modulator complex and uses thereof (International Patent Publication # WO 94/14976) World Intellectual Property Gazette, July 7.
- CT Chu (1993) The Covalent Binding Reaction of a2–Macroglobulin: Effects on Antigen Presentation (Doctoral Dissertation), University Microfilms, Inc, Ann Arbor, MI.
- CT Chu & SV Pizzo (1991) Interactions between cytokines and a2–macroglobulin (letter), Immunol Today 12: 249. PMID: 1716108
- CT Chu (1990) An MD/PhD training pathway with early clinical rotations Doctor Doctor 1: 5.
- CT Chu (1990) Career choices of MD/PhD graduates Doctor Doctor 1: 4.
- CT Chu (1987) Functional Design, Ecology, and Optimality as Exemplified in the Trophic Apparatus of Some Surfperches (Embiotocidae), Harvard University Archives, Cambridge, MA. Thomas T. Hoopes Prize thesis.