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Science is fun!
If you are curious about how things work, or have ideas on how to make things better, science may just be for you. The nature of research is that you do not know the outcome of your experiments until you do them. The most rewarding moments come from the unexpected results -- that moment of inspiration when you discover a new way to fit things together and new questions to ask.

My CanTEEN interview

How long does your trash hang around? From "biodegradable" plastics to Alzheimer's disease

10/22/2013

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So you are doing everything "right" – sorting your landfill trash from recyclables, composting and switching to biodegradable plastic! Yet the question remains as to how long your trash may stay around. Click the button below to link to an experiment by Science Buddies that you can use to test which product really is best. How big a trash heap will build up if you add a new lunch container every day before the first one disappears?
Kid Experiment in Recycling
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Two sick neurons in the brain of a patient that had Alzheimer's disease. A part of the highway system in one cell has formed tangles, and the lysosomes of the other cell are distended by undigested stuff.
Brain cells can live more than 100 years without being "reborn" through cell division. Thus, they have to be efficient in recycling their trash. Two weeks ago, we discussed how the brain cell knows when it needs to to "eat" damaged power plants (mitochondria) before they can leak harmful substances. http://dx.doi.org/10.1038/ncb2837

In Alzheimer's disease, even after the cellular trash has been picked up by autophagosomes (recycling trucks of the cell), something goes wrong and the trash is not broken down in the lysosome. Lysosomes are cellular bags that contain digestive enzymes to break down cellular trash, just as the microorganisms break down biodegradable waste in the Science Buddies Experiment.
Recycling in Brain Diseases
For a lot more details, click above for a review by a top Alzheimer's researcher
http://dx.doi.org/10.1038/nm.3232
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    Scientist, Mother, Physician, Educator. My first paper was on neural programs that control fish feeding, later wandering through macrophage antigen "nibbling", to my current interests in brain autophagy (cellular eating of damaged or unneeded parts). 

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