https://www.jneurosci.org/content/early/2022/09/02/JNEUROSCI.0785-22.2022
We show for the first time that endogenous PINK1 is essential for proper development of key neuronal structures responsible for receiving messages from other cells. The dendrites are like telephone wires stretching out to make numerous contacts with other neurons, and the tiny spines on these dendrites are responsible for receiving signals important for learning and memory.
The study extends our prior findings that overexpression of PINK1 can increase branching of neurons and protect against the harmful dendritic shrinking effects of the parkinsonian toxins 6-OHDA and MPP+. By understanding better processes that trigger PINK1 degradation, we were able to develop a small molecule that elevates endogenous expression of PINK1 to achieve neuroprotection.
These developments may lead to new therapies to help protect the ability of neurons to communicate through synaptic contacts.